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It is the most abundant intracellular antioxidant in human cells and is often called the "master antioxidant" for its central role in redox homeostasis, enzymatic detoxification, and protection against oxidative damage

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The pKa values were obtained using the Marvin Sketch code from Chem Axon

(2) increased blood glucose levels due to stimulation of gluconeogenesis caused by GCs [96,97,98]

It could be that FOXO4-DRI merely lowers the threshold for cells to enter apoptosis after DNA damage